Table of Contents
Biol 568 Advanced Topics in Molecular Genetics
Ch. 23 Controlling Chromatin Structure
PPT Slide
Control of gene expression
Gene expression analyses
Chromatin can have alternative states
Activation of Txn
Equilibrium model
Activation of Txn
Chromatin remodeling
Chromatin remodeling
Chromatin remodeling
Chromatin remodeling
Txn and chromatin remodeling
Chromatin remodeling
Chromatin Remodeling
PPT Slide
Remodeling changes in chromatin
PPT Slide
Remodeling complexes
SWI/SNF
SWI/SNF
SWI/SNF & txn
Remodeling & Txn factors
Transcription factors
Transcripton Factors
PHO system
Remodeling complex is binds to site via activator
TFs may bind to nucleosomal DNA
TFs bind to nucleosomal DNA
Fig 23.7 Requirement for nucleosomal organization
PPT Slide
Histone modification
Histone modifications
Histone modifications
Effects of histone modifications
Histone Acetylation
Histone Acetylation
Histone acetylation and txn activation
Histone acetylation and txn activation
Histone acetylation is reversible
HAT Activity
PPT Slide
HAT Activity
HAT activity, part of holocomplex
Histone Acetylation
HAT activity, overview
Role of histone acetylation
Histone deacetyation ( HDAC)
Histone deacetyation
Histone methylation
PPT Slide
DNA Methylation
Methylation assays
Methylation assays
DNA Methylation
DNA Methylation
DNA Methylation
DNA Methylation
PPT Slide
DNA Methylation
DNA de-methylation
DNA & Histone methylation
Histones exist in alternative states
Chromatin states are interconverted
Remodeling & Activation
PPT Slide
Position effect variegation (PEV)
Inactivate structure propagates
Heterochromatin
Heterochromatin protein 1 ( HP1)
HP1 binding triggers silencing
PPT Slide
Position effect variegation (PEV)
Chromatin analysis
Chromatin Analyses
Chromatin Analyses
PPT Slide
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