Table of Contents
Biol 568 Advanced Topics in Molecular Genetics
Ch 11 Regulatory Circuits
PPT Slide
Regulatory circuits
Regulatory circuits
Regulatory circuits
Regulatory circuits
Regulatory circuits
PPT Slide
Positive and negative regulators
Negative regulators
Positive regulators
Positive Regulator
Positive and negative regulators
Positive and negative regulators
Positive and negative regulators
Positive and negative regulators
Positive and negative regulators
Positive and negative regulators
Negative Regulators
Glucose Repression
Glucose Repression
Glucose Repression
Positive Regulation
CRP activator
cAMP
Positive control by CRP
Positive control by CRP
Positive control by CRP
Consensus sequence for CRP
CRP
lac operon
ara operon
The majority of CRP binding sites are either
CRP and RNA pol Interaction
DNA bending assays
CRP bends DNA
Regulation of lac operon
PPT Slide
The stringency response
Stirngent response
Stringent Factor
Rel A catalyzator for (p)ppGpp synthesis
RelA responds to stringency
pppGpp -> ppGpp
PPT Slide
ppGpp inhibits transcription of RNA
ppGpp controls initiation of rRNA
Control at transcription level
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Control at Translational level
Repressor and ribosome compete for binding site
Translational repressors
Translational regulation via secondary structures of RNA transcript Fig 11.16
Autogenous Regulation of r-operons
r-protein synthesis controlled by rRNA
Phage T4 p 32 is controlled by an autogenous circuit
Aoutogenous circuit of p32
P32 binding efficiency important for autoregulation
P32 Autogenous Regulation
Autoregulation of macromolecules
PPT Slide
Regulation at transcription level
PPT Slide
Attenuation/Termination
PPT Slide
TRAP
PPT Slide
Regulation of trp operon
Trp operon regulation in E. coli
Trp operon in E. coli
Regualtory regions in trp operon
Regulation of trp operon
Tryptophan is absent:
Termination controlled by secondary structures
Ribosome movement affects secondary RNA structue
Trp operon regulation
PPT Slide
Regulation of trp operon
PPT Slide
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